2017

Rykalina, V., Shadrin, A., Lehrach H., Borodina, T.;
qPCR-based characterization of DNA fragmentation efficiency of Tn5 transposomess
Biol Methods Protoc 2017; 2 (1) bpx001. doi: 10.1093/biomethods/bpx001,[Abstract]

Schütte, M. et al.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Nature Communications 8, 10 February 2017, doi:10.1038/ncomms14262, [Abstract]


2016

Huaibiao Li, Lucien Frappart, Jurgen Moll, Anne Winkler, Torsten Kroll, Jana Hamann, Iris Kufferath, Marco Groth, Stefan Taudien, Moritz Schütte, Marie-Laure Yaspo, Heike Heuer, Bodo M.H. Lange, Matthias Platzer, Kurt Zatloukal, Peter Herrlich, Aspasia Ploubidou
Impaired planar germ cell division in the testis, caused by dissociation of RHAMM from the spindle, results in hypofertility and seminoma
Cancer Res August 2016 DOI: 10.1158/0008-5472.CAN-16-0179 [Abstract]

Andreeva TV, Tyazhelova TV, Rykalina VN, Gusev FE, Goltsov AY, Zolotareva OI, Aliseichik MP, Borodina TA, Grigorenko AP, Reshetov DA, Ginter EK, Amelina SS, Zinchenko RA, Rogaev EI.
Whole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies.
Sci Rep
. 2016 May 24;6:26440. doi: 10.1038/srep26440.PMID:27216912 [Abstract]

Klipp, E., Liebermeister, W., Wierling, C., Kowald, A.
Systems Biology – A Textbook, 2., completely revised and enlarged edition
Wiley-VCH, May 2016, ISBN 978-3-527-33636-4 – Wiley-VCH, Weinheim [Abstract]


2015

Ogilvie, L.A., Wierling, C., Kessler, T., Lehrach, H., Lange, B.M.H.
Predictive Modeling of Drug Treatment in the Area of Personalized Medicine.
Cancer Informatics 14(S4) 95–103 doi: 10.4137/CIN.S19330 [Abstract]

Lehrach, H.
Virtual clinical trials, an essential step in increasing the effectiveness of the drug development process.
Public Health Genomics 2015, 6, DOI:10.1159/000441553 [Abstract]

Ogilvie, L.A., and Jones, B.V.
The human gut virome: a multifaceted majority.
Front. Microbiol. 6:918. doi:10.3389/fmicb.2015.00918 [Abstract]

Wierling, C., Kessler, T., Ogilvie, L.A., Lange, B.M.H., Yaspo, M.L., Lehrach, H.
Network and systems biology: essential steps in virtualising drug discovery and development.
Drug Discovery Today: Technologies 15, 33-40. doi:10.1016/j.ddtec.2015.07.002 [Abstract]

Fischer et al.
Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
27 July, 2015. Nature Genetics. doi: 10.1038/ng.3362 [Abstract]

Nzakizwanayo, J., Kumar, S., Ogilvie, L.A., Patel, B.A., Dedi, C., Macfarlane, W.M., Jones, B.V.
Disruption of Escherichia coli Nissle 1917 K5 Capsule Biosynthesis, through Loss of Distinct kfi genes, Modulates Interaction with Intestinal Epithelial Cells and Impact on Cell Health.
PLoS One. 2015 Mar 19;10(3):e0120430. doi: 10.1371/journal.pone.0120430 [Abstract]


2014

Guilhamon, P., Butcher, L., Presneau, N., Wilson G., Feber, A., Paul, D., Schütte, M., Haybaeck, J., Keilholz, U., Hoffman, J., Ross, M., Flanagan, A., Beck, S.
Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
doi:10.1186/s13073-014-0116-0 [Abstract]

Fouhy, F., Ogilvie, L.A., Jones, B.V., Ross, R.P., Ryan, A.C., Dempsey, E.M., Fitzgerald, G.F., Stanton, C., Cotter, P.D.
Identification of Aminoglycoside and β-Lactam Resistance Genes from within an Infant Gut Functional Metagenomic Library
PLoS One, 9(9): e108016. doi:10.1371/journal.pone.0108016 [Abstract]

Henderson, D., Ogilvie L.A., Hoyle, N., Keilholz, U., Lange, B. , Lehrach, H.
Personalized medicine approaches for colon cancer driven by genomics and systems biology: OncoTrack
Biotechnology Journal 2014, 9DOI 10.1002/biot.201400109 [Abstract]

Rykalina, V.N., Shadrin, A.A., Amstislavskiy, V.S., Rogaev, E.I., Lehrach, H., Borodina, T.A.
Exome Sequencing from Nanogram Amounts of Starting DNA: Comparing Three Approaches
PLOS ONE, 9(7): e101154. doi:10.1371/journal.pone.0101154 [Abstract]


2013

Lappalainen, T., Sammeth, M., Friedländer, M.R., Sudbrak, R., et al.
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature, doi:10.1038/nature12531 [Abstract]

Lehrach, H.
DNA sequencing methods in human genetics and disease research.
F1000Prime Reports 2013, doi:10.12703/P5-34 [Abstract]

Röhr, C., Kerick, M., Fischer, A., Kühn, A., Kashofer, K., Timmermann, B., Daskalaki, A., Meinel, T., Drichel, D., Börno, S.T., Nowka, A., Krobitsch, S., McHardy, A.C., Kratsch, C., Becker, T., Wunderlich, A., Barmeyer, C., Viertler, C., Zatloukal, K., Wierling, C., Lehrach, H., Schweiger, M.R.
High-Throughput miRNA and mRNA Sequencing of Paired Colorectal Normal, Tumor and Metastasis Tissues and Bioinformatic Modeling of miRNA-1 Therapeutic Applications.
PLoS One, doi:10.1371/journal.pone.0067461 [Abstract]

Fogeron, M.-L., Müller, H., Schade, S., Dreher, F., Kühnel, A., Scholz, A.-K., Kashofer, K., Zerk, A., Fauler, B., Lurz, R., Herwig, R., Zatloukal, K., Lehrach, H., Gobom, J., Nordhoff, E., Lange, B.M.H.
LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.
Nature Communications, doi:10.1038/ncomms2517 [Abstract]

Regierer, B., Zazzu, V., Sudbrak, R., Kühn, A., Lehrach, H.
Future of medicine: models in predictive diagnostics and personalized medicine.
Adv. Biochem. Eng. Biotechnol., doi:10.1007/10_2012_176 [Abstract]


2012

Dreher,F., Kreitler,T., Hardt,C., Kamburov,A., Yildirimman,R., Schellander,K., Lehrach, L., Lange,B., Herwig,H.
DIPSBC – data integration platform for systems biology collaborations
BMC Bioinformatics, 2012; 13: 85. doi:10.1186/1471-2105-13-85 [Abstract]

Lim, B.N., Choong, Y.S., Ismail, A., Glökler, J., Konthur, Z., Lim, T.S.
Directed evolution of nucleotide-based libraries using lambda exonuclease.
Biotechniques.,doi:10.2144/000113964 [Abstract]

Zazzu, V., Regierer, B., Kühn, A., Sudbrak, R., Lehrach, H.
IT Future of Medicine: from molecular analysis to clinical diagnosis and improved treatment.
N Biotechnol., doi:10.1016/j.nbt.2012.11.002 [Abstract]

Wierling, C., Kühn, A., Hache, H., Daskalaki, A., Maschke-Dutz, E., Peycheva, S., Li, J., Herwig, R., Lehrach, H.
Prediction in the face of uncertainty: a Monte Carlo-based approach for systems biology of cancer treatment.
Mutat Res. 2012 Aug 15;746(2):163-70. doi: 10.1016/j.mrgentox.2012.01.005. Epub 2012 Jan 23. [Abstract]

Schlachter, C., Lisdat, F., Frohme, M., Erdmann, V.A., Konthur, Z., Lehrach, H., Glökler, J.
Pushing the detection limits: the evanescent field in surface plasmon resonance and analyte-induced folding observation of long human telomeric repeats.
Biosens Bioelectron., doi:10.1016/j.bios.2011.11.003 [Abstract]


2011

Schütze, T., Wilhelm, B., Greiner, N., Braun, H., Peter, F., Mörl, M., Erdmann, V.A., Lehrach, H., Konthur, Z., Menger, M., Arndt, P.F., Glökler, J.
Probing the SELEX process with next-generation sequencing.
PLoS One., doi:10.1371/journal.pone.0029604 [Abstract]