Publications

2023

Kendzia, S., Franke, S., Kröhler, T., Golob-Schwarzl, N., Schweiger, C., Toeglhofer, A.M., Skofler, C., Uranitsch, S., El-Heliebi, A., Fuchs, J., Punschart, A., Stiegler, P., Keil, M., Hoffmann, J., Henderson, D., Lehrach, H., Yaspo, M.-L., Reinhard, C., Schäfer, R., Keilholz, U., Regenbrecht, C., Schicho, R., Fickert, P., Lax, S.F., Erdmann, F., Schulz, M.H., Kiemer, A.K., Haybaeck, J., Kessler, S.M.
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer. 
Mol Cancer, 2023 May 30. doi: 10.1186/s12943-023-01787-x [Abstract]

2022

Zacharias, M., Kashofer, K., Wurm, P., Regitnig, P., Schütte, M., Neger, M., Ehmann, S., Marsh, L.M., Kwapiszewska, G., Loibner, M., Birnhuber, A., Leitner, E., Thüringer, A., Winter, E., Sauer, S., Pollheimer, M.J., Vagena, F.R., Lackner, C., Jelusic, B., Ogilvie, L., Durdevic, M., Timmermann, B., Lehrach, H., Zatloukal, K., Gorkiewicz, G.
Host and microbiome features of secondary infections in lethal covid-19. 
iScience, 2022 Sep 16. doi: 10.1016/j.isci.2022.104926. Epub 2022 Aug 13 [Abstract]

Maqsood, Z., Clark, J.C., Martin, E.M., Cheung, Y.F.H., Morán, L.A., Watson, S.E.T., Pike, J.A., Di, Y., Poulter, N.S., Slater, A., Lange, B.M.H., Nieswandt, B., Eble, J.A., Tomlinson, M.G., Owen, D.M., Stegner, D., Bridge, L.J., Wierling, C., Watson, S.P.
Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. 
PLoS Comput Biol. 2022 Nov 28. doi: 10.1371/journal.pcbi.1010708. eCollection 2022 Nov. [Abstract]

Stapor, P., Schmiester, L., Wierling, C., Merkt, S., Pathirana, D., Lange, B.M.H., Weindl, D., Hasenauer, J.
Mini-batch optimization enables training of ODE models on large-scale datasets. 
Nat Commun. 2022 Jan 10. doi: 10.1038/s41467-021-27374-6 [Abstract]

Leyvraz, S., Konietschke, F., Peuker, C., Schütte, M., Kessler, T., Ochsenreither, S., Ditzhaus, M., Sprünken, E.D., Dörpholz, G., Lamping, M., Rieke, D.T., Klinghammer, K., Burock, S., Ulrich, C., Poch, G., Schäfer, R., Klauschen, F., Joussen, A., Yaspo, M.-L., Keilholz, U. 
Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility study. 
Eur J Cancer, 2022 Jul. doi: 10.1016/j.ejca.2022.04.004. Epub 2022 May 12 [Abstract]

Lehrach, H., Curtis, J., Lange, B., Ogilvie, L.A., Gauss, R., Steininger, C., Scholz, E., Kreck, M.
Proposal of a population wide genome-based testing for Covid-19. 
Sci Rep, 2022 Apr 4. doi: 10.1038/s41598-022-08934-2 [Abstract]

Geanta, M., Tanwar, A.S., Lehrach, H., Satyamoorthy, K., Brand, A.
Horizon Scanning: Rise of Planetary Health Genomics and Digital Twins for Pandemic Preparedness. 
OMICS, 2022 Feb. doi: 10.1089/omi.2021.0062. Epub 2021 Dec 1 [Abstract]

2021

Keil, M., Conrad, T., Becker, M., Keilholz, U., Yaspo, M.-L., Lehrach, H., Schütte, M., Haybaeck, J., Hoffmann, J.
Modeling of Personalized Treatments in Colon Cancer Based on Preclinical Genomic and Drug Sensitivity Data. 
Cancers (Basel), 2021 Nov 30. doi: 10.3390/cancers13236018 [Abstract]

Liebs, S., Eder, T., Klauschen, F., Schütte, M., Yaspo, M.-L., Keilholz, U., Tinhofer, I., Kidess-Sigal, E., Braunholz, D.
Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities. 
Oncogene, 2021 Aug doi: 10.1038/s41388-021-01928-w. Epub 2021 Jul 6 [Abstract]

Loreth, D., Schuette, M., Zinke, J., Mohme, M., Piffko, A., Schneegans, S., Stadler, J., Janning, M., Loges, S., Joosse, S.A., Lamszus, K., Westphal, M., Müller, V., Glatzel, M., Matschke, J., Gebhardt, C., Schneider, S.W., Belczacka, I., Volkmer, B., Greinert, R., Yaspo, M.-L., Harter, P.N., Pantel, K., Wikman, H.
CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis. 
Int J Mol Sci, 2021 Jun 29. doi: 10.3390/ijms22136993 [Abstract]

Tsopra, R., Fernandez, X., Luchinat, C., Alberghina, L., Lehrach, H., Vanoni, M., Dreher, F., Sezerman, O.U., Cuggia, M., de Tayrac, M., Miklasevics, E., Itu, L.M., Geanta, M., Ogilvie, L., Godey, F., Boldisor, C.N., Campillo-Gimenez, B., Cioroboiu, C., Ciusdel, C.F., Coman, S., Hijano Cubelos, O., Itu, A., Lange, B., Le Gallo, M., Lespagnol, A., Mauri, G., Soykam, H.O., Rance, B., Turano, P., Tenori, L., Vignoli, A., Wierling, C., Benhabiles, N., Burgun, A.
A framework for validating AI in precision medicine: considerations from the European ITFoC consortium. 
BMC Med Inform Decis Mak, 2021 Oct 2. doi: 10.1186/s12911-021-01634-3 [Abstract]

Loreth, D., Schuette, M., Zinke, J., Mohme, M., Piffko, A., Schneegans, S., Stadler, J., Janning, M., Loges, S., Joosse, S. A., Lamszus, K., Westphal, M., Müller, V., Glatzel, M., Matschke, J., Gebhardt, C., Schneider, S. W., Belczacka, I., Volkmer, B., Greinert, R., Yaspo, M.-L., Harter, P. N., Pantel, K., Wikmann, H.
CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis.
International Journal of Molecular Sciences, 2021 June. doi: 10.3390/ijms22136993 [Abstract]

Kassuhn, W., Klein, O., Darb-Esfahani, S., Lammert, H., Handzik, S., Taube, E. T., Schmitt, W. D., Keunecke, C., Horst, D., Dreher, F., George, J., Bowtell, D. D., Dorigo, O., Hummel, M., Sehouli, J., Blüthgen, N., Kulbe, H., Braicu, E. I.
Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging.
Cancers, 2021 Mar. doi: 10.3390/cancers13071512 [Abstract]

2020

Castro, M., Badra-Azar, N., Kessler, T., Schütte, M., Lange, B., Yaspo, M.-L.
BIOM-43. Glutamate Receptor and Glutamine Metabolism Profiling by Gene Expression Analysis among Patients with High Grade Glioma (HGG).
Neuro-Oncology, 2020 Nov. doi: 10.1093/neuonc/noaa215.042 [Abstract]

Castro, M., Badra-Azar, N., Kessler, T., Schütte, M., Lange, B., Yaspo, M.-L.
BIOM-16. Immunomic Analysis of Glioblastoma (GBM) using Gene Expression Profiling.
Neuro-Oncology, 2020 Nov. doi: 10.1093/neuonc/noaa215.016 [Abstract]

Ogilvie, L. A., Rieke, D. T., Lehrach, H.
A vision: in silico clinical trials without patients. In: Innovation in Clinical Trial Methodologies: Lessons Learned during the Corona Pandemic, ed. Peter Schüler.
Elsevier Academic Press, 2020 Nov, 39-47. ISBN: 978-0-128-24490-6 [Abstract]

Xiao, Y., Buschow, R., Amstislavskiy, V., Busch, J., Kilic, E., Villegas, S. L., Timmermann, B., Schütte, M., Mielke, T., Yaspo, M.-L., Jung, K., Meierhofer, D.
Endocytosis-mediated replenishment of amino acids favors cancer cell proliferation and survival in chromophobe renal cell carcinoma.
Cancer Research, 2020 Oct. doi: 10.1158/0008-5472.CAN-20-1998 [Abstract]

Tanwar, A. S., Evangelatos, N., Venne, J., Ogilvie, L. A., Satyamoorthy, K., Brand, A.
Global Open Health Data Cooperatives Cloud in an Era of COVID-19 and Planetary Health.
OMICS, 2020 Oct. doi: 10.1089/omi.2020.0134 [Abstract]

Leyvraz, S., Schütte, M., Kessler, T., Risch, T., Dörpholz, G., Ochsenreither, S., Rieke, D. T., Amstislavskiy, V., Wierling, C., Klauschen, F., Peuker, C. A., Lamping, M., Jelas, I., Burock, S., Schäfer, R., Lange, B., Ulrich, C., Joussen, A., Keilholz, U., Yaspo, M.-L.
Treatment of metastatic uveal melanoma (mUM) through genomic profiling.
Annals of Oncology, 2020 Sep. doi: 10.1016/j.annonc.2020.08.1265 [Abstract]

Spitaleri, A., Garoli, D., Schütte, M., Lehrach, H., Rocchia, W., De Angelis, F.
Adaptive nanopores: A bioinspired label-free approach for protein sequencing and identification.
Nano Research, 2020 Sep. doi: 10.1007/s12274-020-3095-z [Abstract]

Bornhauser, B., Cario, G., Rinaldi, A., Risch, T., Martinez, V. R., Schütte, M., Warnatz, H-J., Scheidegger, N., Mirkowska, P., Temperli, M., Möller, C., Schumich, A., Dworzak, M., Attarbaschi, A., Brüggemann, M., Ritgen, M., Mejstrikova, E., Hofmann, A., Buldini, B., Scarparo, P., Basso, G., Maglia, O., Gaipa, G., Skoblyn, T-L., te Kronnie, G., Vendramini, E., Panzer-Grümayer, R., Barz, M. J., Marovca, B., Hauri-Hohl, M., Niggli, F., Eckert, C., Schrappe, M., Stanulla, M., Zimmermann, M., Wollscheid, B., Yaspo, M-L., Bourquin, J-P.
The hematopoietic stem cell marker VNN2 is associated withchemoresistance in pediatric B-cell precursor ALL.
blood advances, 2020 Apr, 4052-4064. doi: 10.1182/bloodadvances.2019000938 [Abstract]

Lamping, M., Benary, M., Leyvraz, S., Messerschmidt, C., Blanc, E., Kessler, T., Schütte, M., Lenze, D., Jöhrens, K., Burock, S., Klinghammer, K., Ochsenreither, S., Sers, C., Schäfer, R., Tinhofer, I., Beule, D., Klauschen, F., Yaspo, M-L., Keilholz, U., Rieke, D.T.
Support of a molecular tumour board by an evidence-based decision management system for precisiononcology.
European Journal of Cancer, 2020 Mar, 41-51. doi:/10.1016/j.ejca.2019.12.017 [Abstract]

2019

Schade, S., Ogilvie, L. A., Kessler, T., Schütte, M., Wierling, C., Lange, B. M., Lehrach, H., Yaspo, M. L.
Ein daten- und modellgesteuerter Ansatz zur Behandlung maligner Tumoren.
Der Onkologe, 2019 Aug 27. doi: 10.1007/s00761-019-00652-1. [Abstract]

Schade, S., Ogilvie, L. A., Kessler, T., Schütte, M., Wierling, C., Lange, B. M., Lehrach, H., Yaspo, M. L.
A data- and model-driven approach for cancer treatment.
Der Onkologe, 2019 Aug 12. doi: 10.1007/s00761-019-0624-z. [Abstract]

Ciușdel, CF., Coman, S., Boldișor, C., Kessler, T., Muradyan, A., Kovachev, A., Lehrach, H., Wierling, C., Itu, LM.
Effect of Linearization in a WNT Signaling Model.
Computational and Mathematical Methods in Medicine, 2019 Jun 10. 2019:8461820. doi: 10.1155/2019/8461820.[Abstract]

Gu, W., Yildirimman, R., Van der Stuyft, E., Verbeeck, D., Herzinger, S., Satagopam, V., Barbosa-Silva, A., Schneider, R., Lange, B., Lehrach, H., Guo, Y., Henderson, D., Rowe, A., IMI OncoTrack and the IMI eTRIKS consortia.
Data and knowledge management in translational research: implementation of the eTRIKS platform for the IMI OncoTrack consortium.
BMC Bioinformatics, 2019 Apr 01. doi: 10.1186/s12859-019-2748-y. [Abstract]

2018

Fröhlich, F., Kessler, T., Weindl, D., Shadrin, A., Schmiester, L., Hache, H., Muradyan, A., Schütte, M., Lim, JH., Heinig, M., Theis, FJ., Lehrach, H., Wierling, C., Lange, B., Hasenauer, J.
Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model.
Cell Syst., 2018 Dec 26;7(6):567-579.e6. doi: 10.1016/j.cels.2018.10.013. [Abstract]

Grasse, S., Lienhard, M., Frese, S., Kerick, M., Steinbach, A., Grimm, C., Hussong, M., Rolff, J., Becker, M.,  Dreher, F., Schirmer, U., Boerno, S., Ramisch, A., Leschber,G., Timmermann, B., Grohé, C., Lüders, H., Vingron, M., Fichtner, I., Klein, S., Odenthal, M., Büttner, R., Lehrach, H., Sültmann, H., Herwig, R., Schweiger, M. R.
Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance
Genome Med., 2018 July 20;10:55 doi: 10.1186/s13073-018-0562-1. [Abstract]

Rovito R., Warnatz HJ., Kiełbasa SM., Mei H., Amstislavskiy V., Arens R., Yaspo ML., Lehrach H., Kroes ACM., Goeman JJ., Vossen ACTM.
Impact of congenital cytomegalovirus infection on transcriptomes from archived dried blood spots in relation to long-term clinical outcome.
PLoS One., 2018 July 19;13(7):e0200652. doi: 10.1371/journal.pone.0200652. eCollection 2018. [Abstract]

Sternberg, C., Grubery, W., Eberl, M., Tesanovic, S., Stadler, M., Elmer, DP., Schlederer, M., Grund, S., Roos, S., Wolff, F., Kaur, S., Mangelberger, D., Lehrach, H., Hache, H., Wierling, C., Laimer, J., Lackner, P., Wiederstein, M., Kasper, M., Risch, A., Petzelbauer, P., Moriggl, R., Kenner, L., Aberger, F.
Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma.
Int J Cancer., 2018 July 10; doi: 10.1002/ijc.31724. [Abstract]

Devulapally, P.R., Bürger, J., Mielke, T., Konthur, Z., Lehrach, H, Yaspo, M.L., Glökler, J., Warnatz, HJ.
Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes.
Genome Med., 2018 Apr 27;10(1):34. doi: 10.1186/s13073-018-0542-5. [Abstract]

2017

Ogilvie L.A, Kovachev A., Wierling, C., Lange B.M.H., and Lehrach H.
Models of Models: A Translational Route for Cancer Treatment and Drug
Development. Front. Oncol., 19 September 2017 [Abstract]

Schütte, M., Ogilvie, L.A.,  Rieke, D.T.,  Lange, B.M.H. , Yaspo, M.L. and Lehrach, H.
Cancer Precision Medicine: Why More Is More and DNA Is Not Enough
Public Health Genomics, 2017 Jun 9. doi: 10.1159/000477157, PMID: 28595192 [Abstract]

Rykalina, V., Shadrin, A., Lehrach H., Borodina, T.
qPCR-based characterization of DNA fragmentation efficiency of Tn5 transposomes
Biol Methods Protoc 2017; 2 (1) bpx001. doi: 10.1093/biomethods/bpx001 [Abstract]

Schütte, M. et al.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Nature Communications 8, 10 February 2017, doi:10.1038/ncomms14262 [Abstract]

2016

Li, H., Frappart, L., Moll, J., Winkler, A., Kroll, T., Hamann, J., Kufferath, I., Groth, M., Taudien, S, Schütte, M., Yaspo, M.L., Heuer, H., Lange,  B.M.H., Platzer, M., Zatloukal, K., Herrlich, P., Ploubidou, A.
Impaired planar germ cell division in the testis, caused by dissociation of RHAMM from the spindle, results in hypofertility and seminoma
Cancer Res August 2016 doi: 10.1158/0008-5472.CAN-16-0179 [Abstract]

Andreeva, T.V., Tyazhelova, T.V., Rykalina, V.N., Gusev, F.E., Goltsov, A.Y., Zolotareva, O.I., Aliseichik, M.P., Borodina, T.A., Grigorenko, A.P., Reshetov, D.A., Ginter, E.K., Amelina, S.S., Zinchenko, R.A., Rogaev, E.I.
Whole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies.
Sci Rep. 2016 May 24;6:26440. doi: 10.1038/srep26440.PMID:27216912 [Abstract]

Klipp, E., Liebermeister, W., Wierling, C., Kowald, A.
Systems Biology – A Textbook, 2., completely revised and enlarged edition
Wiley-VCH, May 2016, ISBN 978-3-527-33636-4 – Wiley-VCH, Weinheim [Abstract]

Broecker, F., Hardt, C., Herwig, R., Timmermann, B., Kerick, M., Wunderlich, A., Schweiger, M.R., Borsig, L., Heikenwalder, M., Lehrach, H., Moelling, K.
Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line.
FEBS J., 2016 May;283(9):1669-88. doi: 10.1111/febs.13694. Epub 2016 Mar 25. [Abstract]

Stöger, I., Kocot, K.M., Poustka, A.J., Wilson, N.G., Ivanov, D., Halanych, K.M., Schrödl, M.
Monoplacophoran mitochondrial genomes: convergent gene arrangements and little phylogenetic signal.
BMC Evol Biol., 2016 Dec 16;16(1):274. [Abstract]

2015

Ogilvie, L.A., Wierling, C., Kessler, T., Lehrach, H., Lange, B.M.H.
Predictive Modeling of Drug Treatment in the Area of Personalized Medicine.
Cancer Informatics 14(S4) 95–103 doi: 10.4137/CIN.S19330 [Abstract]

Lehrach, H.
Virtual clinical trials, an essential step in increasing the effectiveness of the drug development process.
Public Health Genomics 2015, 6, doi:10.1159/000441553 [Abstract]

Ogilvie, L.A., and Jones, B.V.
The human gut virome: a multifaceted majority.
Front. Microbiol. 6:918. doi:10.3389/fmicb.2015.00918 [Abstract]

Wierling, C., Kessler, T., Ogilvie, L.A., Lange, B.M.H., Yaspo, M.L., Lehrach, H.
Network and systems biology: essential steps in virtualising drug discovery and development.
Drug Discovery Today: Technologies 15, 33-40. doi:10.1016/j.ddtec.2015.07.002 [Abstract]

Fischer et al.
Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
27 July, 2015. Nature Genetics. doi: 10.1038/ng.3362 [Abstract]

Nzakizwanayo, J., Kumar, S., Ogilvie, L.A., Patel, B.A., Dedi, C., Macfarlane, W.M., Jones, B.V.
Disruption of Escherichia coli Nissle 1917 K5 Capsule Biosynthesis, through Loss of Distinct kfi genes, Modulates Interaction with Intestinal Epithelial Cells and Impact on Cell Health.
PLoS One. 2015 Mar 19;10(3):e0120430. doi: 10.1371/journal.pone.0120430 [Abstract]

2014

Guilhamon, P., Butcher, L., Presneau, N., Wilson G., Feber, A., Paul, D., Schütte, M., Haybaeck, J., Keilholz, U., Hoffman, J., Ross, M., Flanagan, A., Beck, S.
Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
doi:10.1186/s13073-014-0116-0 [Abstract]

Fouhy, F., Ogilvie, L.A., Jones, B.V., Ross, R.P., Ryan, A.C., Dempsey, E.M., Fitzgerald, G.F., Stanton, C., Cotter, P.D.
Identification of Aminoglycoside and β-Lactam Resistance Genes from within an Infant Gut Functional Metagenomic Library
PLoS One, 9(9): e108016. doi:10.1371/journal.pone.0108016 [Abstract]

Henderson, D., Ogilvie L.A., Hoyle, N., Keilholz, U., Lange, B. , Lehrach, H.
Personalized medicine approaches for colon cancer driven by genomics and systems biology: OncoTrack
Biotechnology Journal 2014, 9 doi:10.1002/biot.201400109 [Abstract]

Rykalina, V.N., Shadrin, A.A., Amstislavskiy, V.S., Rogaev, E.I., Lehrach, H., Borodina, T.A.
Exome Sequencing from Nanogram Amounts of Starting DNA: Comparing Three Approaches
PLOS ONE, 9(7): e101154. doi:10.1371/journal.pone.0101154 [Abstract]

2013

Lappalainen, T., Sammeth, M., Friedländer, M.R., Sudbrak, R., et al.
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature, doi:10.1038/nature12531 [Abstract]

Lehrach, H.
DNA sequencing methods in human genetics and disease research.
F1000Prime Reports 2013, doi:10.12703/P5-34 [Abstract]

Röhr, C., Kerick, M., Fischer, A., Kühn, A., Kashofer, K., Timmermann, B., Daskalaki, A., Meinel, T., Drichel, D., Börno, S.T., Nowka, A., Krobitsch, S., McHardy, A.C., Kratsch, C., Becker, T., Wunderlich, A., Barmeyer, C., Viertler, C., Zatloukal, K., Wierling, C., Lehrach, H., Schweiger, M.R.
High-Throughput miRNA and mRNA Sequencing of Paired Colorectal Normal, Tumor and Metastasis Tissues and Bioinformatic Modeling of miRNA-1 Therapeutic Applications.
PLoS One, doi:10.1371/journal.pone.0067461 [Abstract]

Fogeron, M.-L., Müller, H., Schade, S., Dreher, F., Kühnel, A., Scholz, A.-K., Kashofer, K., Zerk, A., Fauler, B., Lurz, R., Herwig, R., Zatloukal, K., Lehrach, H., Gobom, J., Nordhoff, E., Lange, B.M.H.
LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.
Nature Communications, doi:10.1038/ncomms2517 [Abstract]

Regierer, B., Zazzu, V., Sudbrak, R., Kühn, A., Lehrach, H.
Future of medicine: models in predictive diagnostics and personalized medicine.
Adv. Biochem. Eng. Biotechnol., doi:10.1007/10_2012_176 [Abstract]

2012

Dreher,F., Kreitler,T., Hardt,C., Kamburov,A., Yildirimman,R., Schellander,K., Lehrach, L., Lange,B., Herwig,H.
DIPSBC – data integration platform for systems biology collaborations
BMC Bioinformatics, 2012; 13: 85. doi:10.1186/1471-2105-13-85 [Abstract]

Lim, B.N., Choong, Y.S., Ismail, A., Glökler, J., Konthur, Z., Lim, T.S.
Directed evolution of nucleotide-based libraries using lambda exonuclease.
Biotechniques.,doi:10.2144/000113964 [Abstract]

Zazzu, V., Regierer, B., Kühn, A., Sudbrak, R., Lehrach, H.
IT Future of Medicine: from molecular analysis to clinical diagnosis and improved treatment.
N Biotechnol., doi:10.1016/j.nbt.2012.11.002 [Abstract]

Wierling, C., Kühn, A., Hache, H., Daskalaki, A., Maschke-Dutz, E., Peycheva, S., Li, J., Herwig, R., Lehrach, H.
Prediction in the face of uncertainty: a Monte Carlo-based approach for systems biology of cancer treatment.
Mutat Res. 2012 Aug 15;746(2):163-70. doi: 10.1016/j.mrgentox.2012.01.005. Epub 2012 Jan 23. [Abstract]

Schlachter, C., Lisdat, F., Frohme, M., Erdmann, V.A., Konthur, Z., Lehrach, H., Glökler, J.
Pushing the detection limits: the evanescent field in surface plasmon resonance and analyte-induced folding observation of long human telomeric repeats.
Biosens Bioelectron., doi:10.1016/j.bios.2011.11.003 [Abstract]

2011

Schütze, T., Wilhelm, B., Greiner, N., Braun, H., Peter, F., Mörl, M., Erdmann, V.A., Lehrach, H., Konthur, Z., Menger, M., Arndt, P.F., Glökler, J.
Probing the SELEX process with next-generation sequencing.
PLoS One., doi:10.1371/journal.pone.0029604 [Abstract]